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The James & Esther King Biomedical Research Program and the Bankhead-Coley Cancer Research Program issued calls for grant applications December 4, 2009 for FY 2010-11 awards, with an application due date of February 12, 2010.
This message is a reminder that the deadline is approaching soon and also serves as notice that Call Amendments have now been issued for the Bankhead-Coley and King Programs’
Open Call for Grant Applications: Technology Transfer/Commercialization Partnership August 10, 2009 – January 29, 2010.
Applications Due February 12
For FY 2010-11, the King Program is offering New Investigator Research Grants, Research Project Grants, Postdoctoral Research Fellowships, and Team Science Program Grants, all focused on tobacco-related research. Visit www.floridabiomed.com/jek_call for more information about the King Calls for Grant Applications and registration process.
The Bankhead-Coley Program is offering New Investigator Research Grants, Research Project Grants, Postdoctoral Research Fellowships, and Team Science Program Grants, all focused on cancer-related research. Visit www.floridabiomed.com/bc_call for more information about the Bankhead-Coley Calls for Grant Applications and registration process.
To date, we have received nearly 50% more application registrations for Bankhead-Coley Program grants than for King Program grants. When considering a research project that fits the goals of both Programs, be aware that there may be greater competition for Bankhead-Coley grants than for King grants. Both programs are expected to have equivalent levels of funding in FY 2010-11.
Technology Transfer/Commercialization Partnership Call Amendments
Call Amendments have been issued for the Open Call for Grant Applications: Technology Transfer/Commercialization Partnership (TTCP) Grant for both the Bankhead-Coley and the King Programs to extend the close of these two Calls from January 29, 2010 to March 31, 2010. To access the Bankhead-Coley TTCP Call Amendment, click on the following link: Bankhead-Coley TTCP Amendment 1. The original Bankhead-Coley TTCP Call for Cancer grants can be accessed at www.floridabiomed.com/bc_call. To access the King TTCP Call Amendment, click on the following link: King TTCP Amendment 1. The original King TTCP Call for Tobacco-Related Diseases can be accessed at www.floridabiomed.com/jek_call.
We would be grateful if you would circulate this information within your institution and forward it to other Florida colleagues engaged in tobacco- or cancer-related research.
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This is a story about the brown patch of dirt in the foreground and the Jacksonville-based foundation that marshaled millions of dollars and a platoon of political leaders so it could build a children's hospital on it. As illustrated by the ubiquitous backhoes and two stories of rising steel and concrete, Nemours succeeded. Despite its application being rejected twice by state regulators. |
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A discovery by University of Central Florida researchers has revealed a previously unknown mechanism that may cause deterioration of the brain during the earliest stages of Alzheimer's disease, opening up new treatment possibilities. While most Alzheimer's studies have focused on brain cells already damaged by amyloid-beta – or the effects of high concentration of the substance – the University of Central Florida team instead explored impacts of very low amyloid-beta concentrations on healthy cells in an effort to mimic the earlier stages of Alzheimer's. |
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It's not just the growth rate of biomedical funding that's slowing; the total number of dollars seems to be decreasing as well, says a study in this week's Journal of the American Medical Association.
To make matters worse, the funding downturn also corresponds to one of the biomedical industry's most stagnant periods in productivity, measured by the number of new drugs approved by the US Food and Drug Administration, the report notes.
For full study details, visit http://jama.ama-assn.org/cgi/content/full/303/2/137?home#AUTHINFO |
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Florida dreams of becoming a biotechnology hub, a place where the brilliant and the investment-savvy will come to build the economy of the 21st century. Eight years ago, Gov. Jeb Bush was asking legislators to invest $100 million to help Florida challenge the nation's high-tech hot spots for future business in biotechnology and biomedical fields, and the push hasn't stopped. It's the same old story. Stinginess is not the key to success, whether in grade schools or in public universities, in health care or in attracting high-tech industry. You have to spend money to make money. If we don't find the money to invest, Florida's dreams will remain just that.
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The report evaluates the Innovation Incentive Program’s progress toward creating clusters of high wage, high skilled, complementary industries that serve as catalysts for economic growth in regions in which they are located and across the state. It also answers the following four questions:
1. How have Innovation Incentive Program funds been awarded?
2. Does Florida have the characteristics necessary for biotechnology cluster growth?
3. Are biotechnology clusters developing because of the program?
4. What options could the Legislature consider to strengthen
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The announcement today of a $50 million gift to the Burnham Institute for Medical Research will further expand the organization's cutting-edge research at Lake Nona's emerging "medical city" and help it weather the tough economy.
The donation by philanthropist and private equity investor T. Denny Sanford will also result in a name change for the bicoastal organization to the Sanford-Burnham Medical Research Institute.
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Photoacoustic Detection of Melanoma Micrometastasis in Sentinel Lymph Nodes
Journal of Biomechanical Engineering. Vol 131, July 2009. By Devin McCormack and others
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Melanoma is the deadliest form of skin cancer and has the fastest growth rate of all cancer types. Proper staging of melanoma is required for clinical management. One method of staging melanoma is performed by taking a sentinel node biopsy, in which the first node in the lymphatic drainage path of the primary lesian is removed and tested for the presence of melanoma cells. We have developed a photoacoustic method that probes the entire node intact.
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Voxelized Model of Interstitial Transport in the Rat Spinal Cord Following Direct Infusion into White Matter
Journal of Biomechanical Engineering. Vol 131, July 2009. By Jung Hwan Kim and others
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Direct tissue infusion is a promising local delivery for treating diseases of the central nervous system. Predictive models of spatial drug distribution during and following direct tissue infusion are necessary for treatment optimization and planning of surgery. In this study, a 3D interstitial transport modeling approach in which tissue properties are anatomical boundaries are assigned on a voxel-by-voxel basis using tissue alignment data from diffusion tensor imaging is presented.
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Peptide- and Aptamer-Functionalized Nanovectors for Targeted Delivery of Therapeutics
Journal of Biomechanical Engineering. Vol 131, July 2009. By Todd O. Pangburn and others
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Targeted area of therapeutics is an area of vigorous research, and peptide- and aptamer-functionalized nanovectors are a promising class of targeted delivery vehicles. The multitude of peptide ligands that have been used for targeted delivery are covered in this review, with discussion of binding selectivity and targeting performance for these peptide sequences where possible. Targeted delivery of therapeutics by these targeted nanovectors is reviewed with coverage of both in vitro and in vivo deliveries.
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The Deformation Behavior of Multiple Red Blood Cells in a Capillary Vessel
Journal of Biomechanical Engineering. Vol 131, July 2009. By Xiaobo Gong and others
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The deformation of multiple red blood cells in a capillary flow was studied numerically. The immersed boundary method was used for the fluid red blood cells interaction. The membrane of the red blood cell was modeled as a hyperelastic thin shell. The numerical results show that the apparent viscosity in the capillary flow is more sensitive to the change of shear coeffecient of the membrane than that of the bending or surface dilation.
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Nanoparticles for Thermal Cancer Therapy
Journal of Biomechanical Engineering. Vol 131, July 2009. By Emily S. Day, Jennifer G. Morton, and Jennifer L. West
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Advances in nanotechnology are enabling many new diagnostic and therapeutic approaches in cancer. In this review, examples where nanoparticles are employed to induce localized heating within tumors are explored. Approaches to nanoparticle-medicated thermal therapy include absorption of infrared light, radio frequency ablation, and magnetically-induced heating. These approaches have demonstrated high efficacy in animal models, and two are already in human clinical trials. |
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Numerical Simulation of Au Nanoparticles Effect on the PCR Process
Journal of Biomechanical Engineering. Vol 131, Jul 09. By Chao Chen and others
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Gold nanoparticles have been found to greatly enhance the polymerase chain reaction (PCR) speci?city and yield in recent studies. However, the underlying mechanism is still unclear, though different hypotheses have already been proposed. In this study, a mass-action based model has been developed to investigate the effect of Au nanoparticles on the two-round PCR results.
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Dynamic Effect of Heat Shock Pretreatment on Apoptotic Responses to TNF- in Liver Cells
Journal of Biomechanical Engineering. Vol 131, Jul 09 By Sihong Wang and others
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The correlation between apoptosis and heat shock protein (HSP) expression kinetics demonstrates that both high levels of HSPs and proper timing between HS and tumor necrosis factor-a (TNF-a) stress were critical for optimal protection. Our study establishes a dynamic experimental model for further investigation of HS as a potential clinical approach to target tissue survival or death. |
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Frontiers in Biotransport: Water Transport and Hydration
Journal of Biomechanical Engineering. Vol 131, Jul 09. By Alptekin Aksan, Allison Hubel, and John C. Bischof
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Biotransport, by its nature, is concerned with the motions of molecules in biological systems while water remains as the most important and the most commonly studied molecule across all disciplines. In this review, we focus on biopreservation and thermal therapies from the perspective of water, exploring how its molecular motions, properties, kinetic, and thermodynamic transitions govern biotransport phenomena and enable perservation or controlled destruction of biological systems. |
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